25th Summer Institute in Statistical Genetics (SISG)

Module 7: Population Genetics

Wed, July 15 to Fri, July 17

Module dates/times: Wednesday, July 15; Thursday, July 16, and Friday, July 17. Live sessions will start no earlier than 8 a.m. Pacific and end no later than 2:30 p.m. Pacific, except for Wednesdays. For modules that end on Wednesday, live sessions will end by 11 a.m. Pacific. For modules that start on Wednesday, live sessions will begin no earlier than 11:30 a.m.

This module considers the analyses now possible for whole-genome sequence data collected on large numbers of individuals. Specific topics include characterization of de novo mutations and the comparison of growth rates among populations. Sequence data allow detailed examination of the signatures of natural selection and methods to compare selective constraints across populations and to seek evidence for recent, population-specific adaptation will be covered. The analysis of identity-by-descent segment sharing, and random projection for IBD detection (RaPID) to infer demographic history will be covered, as will methods to reconstruct the genetic architecture of major human diseases. Suggested pairing: Modules 8 and 12.

Access 2019 course materials.

Learning Objectives: After attending this module, participants will be able to:

  1. Identify the assumptions of Hardy-Weinberg Equilibrium, and how deviations from these assumptions affect patterns of genetic variation.
  2. Simulate data under both the Wright-Fisher model as well as the Coalescent.
  3. Identify population structure using principal components analysis, Structure, and spatially explicit methods.
  4. Infer signatures of natural selection using haplotype based methods.
  5. Simulate and measure the genetic architecture of complex traits.