This new module is designed to follow Module 9: Advanced Population Genetics, and provides an alternative to Module 11: Mixed Models in Quantitative Genetics targeted at complex human populations.

This module uses the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) as a case study, but the methods apply to all situations with multiple ethnic groups, admixture, and relatedness. The HCHS/SOL study has collected extensive clinical data and been extensively characterized with genome-wide array data and, more recently, with whole genome sequencing data.

The module covers the use of linear mixed models (LMM) and generalized estimating equations (GEE), with further discussion of pooled and stratified analysis, as well as admixture mapping. It includes use of the SUGGEN and GENESIS packages.

After this module, we expect that students should be able to begin the analysis of HCHS/SOL genetic data and further will become familiar in general with the analysis of complex data which may encompass multiple ethnic groups, admixture, and relatedness.