This new module builds on Module 5: Population Genetic Data Analysis and considers the analyses now possible for whole-genome sequence data collected on large numbers of individuals.

Specific topics include characterization of de novo mutations and the comparison of growth rates among populations. Also covered, how sequence data allow detailed examination of the signatures of natural selection and methods to compare selective constraints across populations and to seek evidence for recent, population-specific adaptation. The analysis of identity-by-descent segment sharing and random projection for IBD detection (RaPID) to infer demographic history will be covered, as will methods to reconstruct the genetic architecture of major human diseases.